Among the most auspicious findings of neuroscience in recent years is the mutability of brain connectivity. In allowing for an increased integration of the study of brain with the study of mind, it deepens our understanding of affect and cognition and of the perceptual and imaginative dimensions of the psyche. It is the primary objective of this article to investigate what the young discipline known as neuroaesthetics brings to our understanding of Beckett’s creativity and how it enriches our scholarship. Focusing (...) on Beckett’s preoccupation with memory, resituating this preoccupation within the arena of the Default Mode Network — in which reference to self is spontaneous and in some sense deeply related to the freely associative speech of the “talking cure” — leads to several conclusions: The most significant include the potentially therapeutic value Beckett derived from writing (change in the mind being a function of change in the brain) and to the justification for recontextualizing psychohistory (speculative at best) as psychobiology. (shrink)